Body Surface Area (BSA): Formula and Medical Significance
Mosteller formula, normal values and clinical applications
The body surface area (BSA) is the total surface area of the human skin, expressed in square meters. It is an important medical parameter, since certain physiological measures and medication dosages are based on BSA. The most commonly used formula is the Mosteller formula (1987): BSA (m²) = √(height in cm × weight in kg / 3600).
The elegant reference example illustrates the formula perfectly: for a person 180 cm tall weighing 80 kg, √(180 × 80 / 3600) = √(14,400 / 3600) = √4 = 2.00 m². This round number makes the example an ideal memory aid for the Mosteller formula and shows that a normal-weight adult of average build can have a BSA of exactly 2 m².
Clinically, BSA is especially central in oncology. Many chemotherapy drugs are dosed in mg/m² BSA, because BSA predicts the pharmacological distribution volume and renal clearance better than body weight alone. A drug dosed at 50 mg/m² would be given as 90 mg to a patient with 1.8 m² BSA, and as 100 mg at 2.0 m². Choosing the correct dose can significantly affect treatment efficacy and toxicity.